Mark,
d**n good question... For offline flight, your only choice would be to look for a weather report for dep/dest and try to figure out the runways that way... easy for fields with a single runway, more difficult if they have multiple runways and/or specific procedures for choosing the active.
If you are flying online, and both dep/dest have APP/DEP or lower facilities open, you can use ServInfo/IvAe to get the controllers ATIS prior to flying; otherwise, you're stuck with using teh intarweb to look for local procedures information.
Hope that helps you some.